The antidiabetic effect of jejunal exclusion surgery for T2DM rats

Objective To study the curative effects of jejunal exclusion surgery for STZ-induced T2DM SD rats. Methods 60 SD rats were induced to be the T2DM SD rats by intraperitoneal injection of streptozotocini. As a result, 55 T2DM SD rats were successfully acquired which were randomly divided into 3 groups, 20 rats in the jejunal exclusion group (A) , 20 rats in the sham operation group (B) and 15 rats in the control group (C) . Jejunal exclusion surgery was performed in group A, jejunojejunostomy was performed in group B, and group C were fed normally. The body weight, fasting blood glucose, fasting plasma insulin level and GLP-1 level were measured before operation and at the 1st, 2nd, 4th, 8th and 16th week after operation. Results As compared with that before operation and that of the control group, the body weight in group A markedly declined at the 2nd, 4th, 8th and 16th week (352.14±9.00, 342.84±8.90, 336.64±10.26, 330.34±9.12, P<0.05) . The fasting plasma glucose levels in group A markedly declined at the 2nd, 4th, 8th and 16th week (14.62±1.10, 12.12±1.38, 8.75±1.06, 7.55±1.00, P<0.05) . The fasting plasma insulin level in group A was markedly increased at the 2nd, 4th, 8th and 16th week (14.62±3.10, 16.12±3.38, 17.75±4.06, 17.55±3.10, P<0.05) . GLP-1 level in group A was markedly increased at the 1st, 2nd, 4th, 8th and 16th week (11.02±0.85, 14.42±1.18, 16.02±1.59, 17.62±1.02, 18.12±0.71, P<0.05) . Conclusions The jejunal exclusion surgery is effective in controlling blood glucose, which is an ideal and lasting method. This surgery has also showed influence on body weight. Key words: Jejunal exclusion; Type 2 diabetes mellitus; Blood glucose