Abstract 15313: Novel Single-Nucleotide Polymorphisms Predict Inverse Association With Non-Pulmonary Vein Triggers in Patients With Paroxysmal Atrial Fibrillation: Results From a Prospective Study (DECAF)

Introduction: Although pulmonary veins (PV) are major sites of ectopic triggers initiating paroxysmal AF (PAF), triggers arising from non-PV sites also play a critical role in origination of PAF. As the exact mechanism of origin of the non-PV triggers is not known yet, we hypothesized that some common genetic variants are associated with the occurrence of these triggers. To examine our hypothesis we evaluated the association of several AF-specific genetic variants with prevalence of non-PV triggers in PAF patients undergoing catheter ablation. Methods: Four hundred AF patients (67% male, 62±12 year, left atrial size 45.3±7 mm, 64% non-paroxysmal) undergoing catheter ablation were prospectively enrolled. DNA extraction and genotyping for 16 AF-associated SNPS were performed from collected blood samples using Qiagen QiaAMP 96 well blood kit and TaqMan assay respectively. Three hundred seventy-two DNA samples were available for genotyping. Multivariate logistic regression analysis (adjusted covariates: age, ...