1538-P: Quality of Life Decrements for Complications of Type 2 Diabetes

To estimate the quality of life decrement associated with complications of type 2 diabetes, we combined public-use data on type 2 diabetes patients from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, its follow-on ACCORDION study, and the Action for Health in Diabetes (Look AHEAD) trial. The ACCORD trial administered the Health Utilities Index Mark 3 (HUI-3) instrument periodically, while the Look AHEAD trial administered the HUI-3 every 6 months. Measurements less than 1 year after a complication were associated with the complication event, and measurements more than 1 year after a complication were associated with a history of the complication. We used a fixed-effects model and included controls for BMI, duration of diabetes, and smoking. In total, there were 99,594 person-visit observations in our estimation sample, representing 14,899 unique persons with an average follow-up of 7.5 years. All complication events and complication history indicators negatively affected quality of life. The largest effects were observed for stroke (event year: 0.086; history: 0.056), congestive heart failure (event year: 0.043; history: 0.054), eGFR Disclosure S. Neuwahl: None. T.J. Hoerger: Research Support; Self; Sanofi. Funding Centers for Disease Control and Prevention