DNA probe detection within 3D hydrogel matrix in a hollow core photonic crystal fibre
2011
In this paper, we report for the first time the detection of a Cy5-labelled DNA probe immobilised within a 3D hydrogel
matrix formed, inside a hollow core Photonic Crystal Fibre (HC-PCF). We show both the sensitivity of fluorescence
detection inside the HC-PCF using a supercontinuum light source and of the variation of the luminescence intensity with
the concentration DNA probe within the hydrogel. The 3D hydrogel matrix is a network of polymer chains, which is
expected to provide highly sensitive detection and selection of bio-molecules, in comparison with 2D coverage. The
biocompatibility of hydrogel in the HC-PCF suggests numerous applications associated with immobilised DNA probe
detection for point-of-care or remote systems.
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