GW25-e0540 Pharmacogenetics of clopidogrel responsiveness in Chinese patients with acute coronary syndrome

Cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogel metabolism. Genetic polymorphisms in these genes have been associated with the variability of the response to clopidogrel, however, there are controversies over the findings.