Resveratrol inhibition of Propionibacterium acnes

Results: After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC50 )w as 73 mg/L and the average 100% inhibitory concentration (IC100) was 187 mg/L for the three strains of P. acnes tested. The IC50 and IC100 of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic. Conclusions: Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.