Skeletal effects of estrogen analogs

Estrogens clearly have beneficial effects on the skeleton of postmenopausal women. The development of the agents that act like estrogens in the skeleton but may have a different pattern of effect in other tissues, suggests the possibility that tissue-selective estrogens may become important in the management of post-menopausal women in the future, especially those who may be at risk of osteoporosis. Greater understanding of the action of these tissue-selective estrogens will allow the development of a novel compound with profiles that may target more definitively the needs of the postmenopausal population.