Abstract 14022: Associations Between Testosterone Levels and Mortality in Male Patients With Heart Failure

Background: The age-related decline of circulating anabolic hormones in male is associated with increased morbidity and mortality. It has been reported that anabolic deficiency is associated with cachexia in patients with heart failure (HF). Thus, we aimed to investigate the impact of testosterone on prognosis of HF and underlying cardiac function, cardiac damage and exercise capacity. Methods and Results: We analyzed consecutive 618 male patients with HF (age 65.9 years), who admitted to our hospital. These patients were divided into 4 groups based on the serum levels of total testosterone (TT): 1st (TT >631 ng/dl, n=154), 2nd (462< TT ≤631 ng/dl, n=155), 3rd (300< TT ≤462 ng/dl, n=156) and 4th (TT ≤300 ng/dl, n=153) quartiles. Although age did not differ among the groups, in the Kaplan-Meier analysis (mean 1281 days), all-cause mortality progressively increased from 1st to 2nd, 3rd and 4th groups (Figure). In the Cox proportional hazard analysis, after adjusting for other potential confounding factors, ...