ADRENOMEDULLİN VE DİYABET Adrenomedullin And Diabetes

OZET Adrenomedullin (ADM) son donemde kesfedilen, cok fonksiyonu olan bir peptiddir. Karakteristik etkileri arasinda vazodilator etkisi ve hipotansif ozellikleri yer almaktadir. Farkli organlarda yaygin bir uretim ve ekspresyonunun oldugu dusunuldugunde ADM, cesitli biyolojik sistemlerde otokrin, endokrin ya da parakrin bir mediyator olarak rol oynayabilir. Plazma ADM duzeylerinin cesitli hastaliklarda artmasi, ADM’nin hastalik durumlarinda olasi bir modulator rolune isaret etmektedir. Kardiyovaskuler hastaliklarda ve diyabette plazma ADM duzeyleri artmaktadir ve bu durum hep tip 1 hem de tip 2 diyabette gozlenen diyabetik komplikasyonlar ile iliskilidir. Kardiyovaskuler hastaliklardaki bulgulardan farkli olarak, diyabette gozlenen ADM duzeylerindeki bu artis, tam olarak aciklanamamistir. Bu yuzden son donemdeki arastirmalar ADM ve diyabet arasindaki iliskiye yogunlasmistir. ADM’nin glukoz metabolizmasi ve insulin dengesinin saglanmasinda bir rol oynadiginin gosterilmesi, ADM-diyabet iliskisine dair bir ipucu olusturmaktadir. Bu derlemede ADM’nin diyabetteki rolune dair yapilan calismalar uzerinde durulmustur Anahtar Sozcu¨kler: Adrenomedullin; Diyabet; Kalsitonin geniyle iliskili peptid (CGRP); Siklik adenozin monofosfat (sAMP); Vazodilatasyon ABSTRACT Adrenomedullin (ADM) is a novel peptide that has a wide range of functional effects discovered in recent years. ADM has vasodilator and hypotensive effects. Considering widespread production and expression of ADM in different tissues, ADM could play as an endocrin, paracrin or otocrin roles in different biological systems. Increasing of plasma ADM levels in different pathological diseases, indicate possible modulator role of ADM in these diseases. It was shown that plasma ADM levels were increased in cardiovascular diseases and diabetes and is associated with diabetic complications in both type 1 and 2 diabetes. But, different from the findings in cardiovascular diseases, the definition and significance for such an increament is not clear. Therefore, recent studies has been concentrated on the association between ADM and diabetes. Showing ADM plays a role in glucose metabolism and insulin balance, these evidence might obtain clue on the involvement of ADM in diabetes. In this review, we try to summary the existing studies about the role of ADM in diabetes. Keywords: Adrenomedullin; Diabetes; Calcitonin gene-related peptide (CGRP; cyclic adenosine monophosphate (cAMP); Vasodilation.