Electrochemical and in vitro bioactivity behavior of poly (ε-caprolactone) (PCL)-gelatin-forsterite nano coating on titanium for biomedical application

Abstract In this study, in order to improve the biological, chemical, and mechanical properties of titanium, poly (e-caprolactone) (PCL) - Gelatin (Gel) - forsterite nano composite coating is performed on the titanium substrates. First, a uniform suspension of PCL-Gel-forsterite nano composite was prepared and then, titanium substrates were dip coated in it and then an individual nanofiber coating was employed on the first layer coating via electrospinning method. The characterization of PCL-Gel-forsterite nano composite coated samples was determined through scanning electron microscopy (SEM), X-ray diffraction (XRD). The outcome indicates a uniform nanofibrous coating containing 2 wt % forsterite nanoparticles and various amounts of the PCL were produced. The corrosion resistance of the ceramic-polymer nano fibrous coating was investigated in phosphate buffered saline solution (PBS) using electrochemical impedance spectroscopy (EIS) and it is proved that the nanofibrous coating significantly improve the corrosion resistance of the titanium substrate. At the end the cellular responses of produced nanofibers to MG63 cells were evaluated and cell viability results showed that bioactivity improved with decreasing GEL content confirming the potential application of PCL-Gel-forsterite nanofibrous composite coating for biomedical applications.