Comparative experimental study between retrograde cerebral perfusion and circulatory arrest

To evaluate the efficacy of retrograde cerebral perfusion in protecting the brain, we comparatively studied retrograde cerebral perfusion and total circulatory arrest in 18 hypothermic (20 o C) mongrel dogs (retrograde cerebral perfusion, n=10; total circulatory arrest, n=8). Retrograde cerebral perfusion was performed, maintaining an external jugular venous pressure of 25 mm Hg for 60 minutes. Retrograde cerebral perfusion provided half the cerebral blood flow and a thud of the oxygen that was supplied during hypothermic cardiopulmonary bypass, which bad a flow rate of 100 ml/min per kilogram