Ultrasound‐assisted skin diagnostics

The biomolecular composition of human skin, represented by a multitude of lipids, proteins, nucleic acids, and other miscellaneous molecules, is a sensitive indicator of skin’s local health, as well as the body’s systemic health. However, this information is not easily accessible, and consequently not used in the current diagnostic methods. To address the lack of quantitative methods for non‐invasive skin diagnostics, herein, we describe the use of ultrasound to rapidly extract biological markers from skin. Specifically, we extracted several types of proteins (keratins, beta‐actin, cytokines, and others), lipids (cholesterol, ceramides, fatty acids, and others), nucleic acids, small molecules (natural moisturizing factors and exogenous molecules), and microbes enabling us to create skin’s unique biomolecular signature. The extracted biomolecules showed quantitative correlations with their composition in the epidermal skin. Extraction of these entities from skin using our method is convenient and reproduci...