AKI due to COVID-19 in the intensive care unit: Analysis of a Brazilian Center

Background: The kidney may be affected by coronavirus (COVID) in the setting of acute kidney injury (AKI) or glomerular diseases Data about AKI in Intensive Care Unit (ICU) patients of Latin-America are scarce The aim of this study is evaluate the risk of AKI, dialysis (HD) and death in ICU patients diagnosed with COVID pneumonia in a brazilian center Methods: Analysis from medical records of ICU patients with diagnosis of COVID pneumonia in a brazilian single-center AKI was defined according to KDIGO criteria Results: During the period of February 2nd to May 4th, 95 ICU patients diagnosed with COVID were analyzed There was predominance of male (64 2%), median age of 64 9 years, previous diagnosis of hypertension, diabetes and obesity in 51 6%, 27 4 and 30 5% respectively AKI was diagnosed in 54 (56 8%) patients and 32 (59 2%) of them required HD Mortality rate was 17 9% Patients with AKI, compared to no-AKI were statisticaly significant more frequently hypertensive and diabetic, worse SAPS3 and SOFA scores and need for organ support therapies Laboratory tests depicted more anemia, lymphopenia, and higher levels of inflamatory markers as well as longer lenght of stay in ICU, hospital and death Similar findings were seen in those ones who required HD compared to those with conservador treatment Comparing patients who undergone death to survivors, they were older, more frequently diabetic, worse SAPS3 and SOFA scores and need for organ support therapies, AKI and dialysis Multinomial logistic regression predicted that hypertension (p=0 01), mechanical ventilation (p=0 01) and use of hydroxychloroquine (p=0 009) were independent risks factors for AKI;hypertension (p=0 002), mechanical ventilation (p=0 03), use of vasopressor (p=0 04), and use of hydroxychloroquine (p=0 009) for HD patients;and age >;65 years (p=0 03) and AKI (p=0 04) for death Conclusions: In our study, AKI was a common complication of ICU COVID patients, it was associated to hypertension, organ support therapies and use of hydroxichloroquine As well as age >;65 years, AKI was an independent risk fator to death