Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

Ryo Okada,Xinwen Zhang,Yuka Harada,Zhou Wu,Hiroshi Nakanishi

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

2018

Ryo Okada
Xinwen Zhang
Yuka Harada
Zhou Wu
Hiroshi Nakanishi

Objective The objective of this study is to investigate the role of cathepsin H (CatH), a lysosomal cysteine protease, in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis.

Keywords:

Biology
Toll-like receptor
Dendritic cell
Biochemistry
Immunology
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Cysteine protease
Microglia
Cathepsin H
Cathepsin S
cell activation

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