Pharmacological characterization of Cirsium ligulare Boiss. (Asteraceae) herb decoction
2017
Background/Aim. Data on phytochemical and pharmacological investigations of
genus Cirsium Mill. (Asteraceae) are scarce. Some data suggest that
decoctions or infusions prepared from these plants are used in folk medicine
as tonics, particularly in inflammatory, liver and stomach diseases. So far
there have been no pharmacological investigations related to Cirsium ligulare
Boiss. Accordingly, the aim of this study was to estimate antioxidative,
anti-inflammatory and gastroprotective activities of aqueous extracts of C.
ligulare herb prepared as 5% and 10% decoctions. Methods. Antioxidative
activity was determined using the method of DPPH radical scavenging.
Investigations of anti-inflammatory (a model of systemic inflammatory
response induced by endotoxin of Escherichia coli and carrageenan-induced rat
paw oedema model for local inflammatory response), as well as
gastroprotective effects (a model of stress-ulcer induced by absolute
ethanol), were conducted in adult female Wistar rats that were given the
aqueous extracts of C. ligulare herb per os. Indomethacin and ranitidine were
used as reference drugs for evaluation of local anti-inflammatory and
gastroprotective effects, respectively. Results. The results demonstrated
that aqueous extracts of C. ligulare herb produced strong antioxidative
activity, diminished body weight loss induced by endotoxin, significantly
reduced carrageenan-induced paw oedema, and prevented ulcerogenic action of
absolute ethanol. Both anti-inflammatory and gastroprotective activities of
the extract tested were comparable to those of the reference drugs.
Conclusion. Presented results justify the traditional use of C. ligulare herb
decoctions and further phytochemical and pharmacological investigations are
warranted. [Projekat Ministarstva nauke Republike Srbije, br. 173021]
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
26
References
0
Citations
NaN
KQI