Intra- and Inter-Individual Variation of Serum Angiotensin Converting Enzyme: Clinical Implications

The potential usefulness of measurements of serum angiotensin converting enzyme activity (SAC E) was examined using data on the analytical and biological variation in IS ostensibly healthy subjects. Since there is evidence that biological variation in health and stable disease is of the same order, irrespective of whether the analyte is within or outside reference intervals, I the findings should be relevant to the use ofSACE assays in sarcoidosis.