UNCORRECTED PROOF 1 Clinical spectrum of non-alcoholic fatty liver disease in diabetic and 2 non-diabetic patients☆

article i nfo of 503 patients with biopsy proven NAFLD. Comparisons between patients with and without DM were analysed. 28 NFS was correlated with liver histology to assess its robustness in patients with and without DM. 29 Results: There were 503 biopsy proven NAFLD patients with 48% of the cohort being diabetic. Relative to patients 30 withoutDM,patientswithDMwereolder(52vs.46 years,pb 0.001),withhigherproportionoffemales(70% vs. 31 54%, p b 0.001), higher BMI (37 vs. 35, p = 0.009), higher prevalence of hypertension (73% vs. 44%, p b 0.001), 32 higherprevalenceofNASH(80.2%vs. 64.4%;pb 0.001)andadvanced fibrosis (40.3% vs. 17.0%; pb 0.001) Q10 .Acon- 33 siderable amount of patients without DM still had NASH (64%) and advanced fibrosis (17%). The clinicalutility of 34 the NFS differed between NAFLD patients with and without DM, with sensitivity to exclude advanced fibrosis 35 being 90% of NAFLD patients with DM but only 58% of patients without DM.