Deregulation of carbohydrate metabolism in patients with sleep apnoea

Material and methods: The study included 103 new patients with the following characteristics: 50±12 years of age, BMI 30.2±5.8 kg/m2, neck circumference 42±7 cm, Epworth 11±10, AHI 33±27 h-1, DI 34±28 h-1, mean SpO2 91±9% minimum SpO2 76±14%, CT 90 22±30%. Diabetic patients were excluded. Patients underwent blood tests and sleep studies. Results: When comparing a group of patients with OSAS to a control group, there were significant differences in NGSP HbA1c and IFCC HbA1c (p<0,037). There was significant linear correlation between glucose and age (r=0,21). NGSP HbA1c (%) with AHI (r=0,35), minimum SpO2 (r=-0,26), ODI (r=0,37), age (r=0,38). The same for IFCC HbA1c. Insulin with BMI (r=0,39). QUICKI index with AHI (r=-0,28), with ODI (r=-0,30), with BMI (r=-0,47) and with neck circumference (r=-0,26). The HOMA-IR index with BMI (r=0,40). To find possible determinants of NGSP HbA1c (%), the following multiple linear regression model was used: NGSP HbA1c (%)= 4,818+0,011\*Age+0,005\*ODI (r 2 =0,23, p<0,003). Conclusions: 1) Patients with OSAS show higher levels of NGSP HbA1c and IFCC HbA1c. 2) There were significant correlations between some hydrocarbon metabolism parameters/indices and clinical/sleep parameters. 3) Using the regression model, the NGSP HbA1c variability is explained in 23.3% of cases by age and oxygen desaturation index.