(−)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of β1 adrenoceptor via GRK2 in experimental heart failure

Qi Zhang,Li-qun Hu,Li Chen,Hong-qi Li,Jun Wu,Wenting Liu,Mengyuan Zhang,Guang Yan

(−)-Epigallocatechin-3-gallate, the major green tea catechin, regulates the desensitization of β1 adrenoceptor via GRK2 in experimental heart failure

2018

Qi Zhang
Li-qun Hu
Li Chen
Hong-qi Li
Jun Wu
Wenting Liu
Mengyuan Zhang
Guang Yan

Objective We investigated the effect of (−)-epigallocatechin-3-gallate (EGCG) on cardiac function and its mechanism, which focused on the desensitization of β1-AR and GRK2 in heart failure (HF) rats.

Keywords:

Desensitization (telecommunications)
Diabetes mellitus
Biochemistry
Heart failure
Cardiac function curve
Tea catechin
Adrenergic receptor
Medicine
Pharmacology
Gallate
Beta adrenergic receptor kinase
green tea
β1 adrenoceptor
Catechin

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