Unruptured intracranial aneurysms: initial and follow-up screening

Subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm is a devastating disease that causes death or severe disability in half of patients. Intracranial aneurysms are not present at birth but develop during life. Actively searching and treating intracranial aneurysms before rupture may prevent SAH as a result of these aneurysms. The prevalence of intracranial aneurysms is approximately 2% in the general population, but higher in subgroups such as patients who have survived an episode of SAH, persons with a family history of SAH and patients with polycystic kidney disease. Screening for intracranial aneurysms should be considered in these high-risk groups. Some of the intracranial aneurysms detected with screening will be too small to be treated, and may therefore be followed over time, which can cause anxiety in the patient. In this article, we discuss current knowledge, remaining questions and future perspectives in screening and follow-up imaging for unruptured intracranial aneurysms.