Оценка лабораторных показателей, характеризующих функциональное состояние гемопоэза у онкогематологических больных на фоне высокодозной химиотерапии и аутотрансплантации гемопоэтических стволовых клеток

The paper analyzes peripheral blood findings from 34 patients (276 tests) at different time points following high-dose polychemotherapy and autologous hemopoietic stem cell transplantation. Most patients had resistant disease. Blood samples were tested for 26 parameters including reticulocytes, reticulocyte and platelet indices. Ferritin, soluble transferring receptor contents, endogenous erythropoietin were measured. Most patients had anemia before high-dose chemotherapy identified as chronic anemia with high or normal ferritin levels and erythropoietin production not adequate to anemia degree. Testing for young platelet, reticulocyte forms and their indices was shown highly informative for prediction of hemopoiesis recovery start.