High flow nasal cannula oxygen (hfnc) versus non-invasive positive pressure ventilation (nippv) in acute hypoxemic respiratory failure. a pilot randomized controlled trial

2015 
Oxygen therapy is generally provided via nasal cannula, non-rebreathing masks and masks with reservoir bags. These devices have various limitations. Despite showing clear benefits in certain conditions, non-invasive positive pressure ventilation (NIPPV) limits mobilization, restricts communication and oral nutrition and is poorly tolerated by some patients due to discomfort. High-flow nasal cannula oxygen (HFNC) delivers a high flow of heated and humidified oxygen through nasal prongs. It generate positive airway pressure, reduces respiratory dead space, airway resistance, and less frequent interruption of therapy.
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