AB0431 EFFECTS OF LOW-LOAD RESISTANCE EXERCISE OF LOW EXTREMITY IN WOMEN WITH RHEUMATOID ARTHRITIS

Background Some skeletal muscles communicate with other organ by secreting proteins and peptides called myokine. Some myokines have anti-inflammatory effect1). As regards rheumatoid arthritis (RA), many studies have shown that aerobic and resistance exercise programs do not change the number of inflammatory joints and RA disease activity, whereas other studies showed improved the marker. And almost studies were performed by high-load resistance training protocols. Meanwhile lately Schoenfeild showed that muscle hypertrophy can be equally achieved across a spectrum of load ranges with meta-analysis2). Objectives To investigate the efficacy of low-load resistance exercise of low extremity protocol on RA. Methods Twenty-four patients with RA were enrolled. Inclusion criteria were receipt of a stable dose of biologics, JAK inhibitory, and conventional DMARDs more than 3months prior to the first exercise, and corticosteroid and NSAIDs more than one month prior to the first exercise. The exercise circuits consisted of 6 different low extremity exercises intended to improve arthritis. Within the exercise circuits, each exercise was repeated 8-12 times and less than 50% of the 1-repitition maximum. The exercise circuits were performed 3 times a week. Disease activity parameters and inflamed joint of upper extremity and lower extremity were collected at base line and 2 months after exercise started. The Wilcoxon signed-rank test was used to examine the difference between the parameter of the base line and the 2 months. Results All patients were female. Mean age was 68.7 years., and mean disease duration 15.3 years. Seven patients (29%) used methotrexate, 5 patients (21%) used prednisolone and 13 patients (54%) used biologics. Mean DAS28(ESR) was 3.98 at base line and 3.58 at 2 months, mean DAS28(CRP) 3.46 and 3.06, mean SDAI 15.4 and 12.5, and mean CDAI 14.5 and 11.5, and mean upper extremity joint tenderness 4.7 and 3.7, mean upper extremity joint swelling 1.6 and 1.8, mean lower extremity joint tenderness 5.8 and 2.2, mean lower extremity joint swelling 4.0 and 2.0 respectively. Every index except upper extremity joint swelling improved significantly (p Conclusion Low intensity exercise of low extremity was efficacious against not only lower extremity arthritis but also upper extremity joint arthritis in patients with rheumatoid arthritis References [1] Fabiana B Benatti, Bente K Pedersen: Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation. Nat Rev Rheumatol 11: 86-97, 2015. [2] Brad J Schoenfeld, et al.: Strength and hypertrophy adaptations low- vs. high-load resistance training a systemic review and meta-analysis. Strength Cond Res 31(12): 3508-3523, 2017 Disclosure of Interests None declared