Changes of N-terminal pro-brain natriuretic peptide levels before and after percutaneous coronary intervention in patients with acute coronary syndrome

Objective To investigate the changes and the significance of N-terminal pro-brain natriuretic peptide levels before and after percutaneous coronary intervention in patients with acute coronary syndrome.Methods Ninety-nine cases of acute coronary syndrome were divided into acute myocardial infarction group(n=56) and unstable angina group(n=43).All cases were performed percutaneous coronary intervention.N-terminal pro-brain natriuretic peptide level was detected in all cases before coronary angiography,immediately and 7 days later after percutaneous coronary intervention.The influence of N-terminal pro-brain natriuretic peptide on the main adverse cardiovascular events were observed in postoperative three months in all cases.Results N-terminal pro-brain natriuretic peptide levels were(776.8±219.2) pg/mL and(351.2±123.4) pg/mL before coronary angiography,(963.6±315.3) pg/mL and(372.5±142.1) pg/mL immediately after percutaneous coronary intervention,and were(443.7±188.5) pg/mL and(275.6±98.2) pg/mL 7 days after percutaneous coronary intervention in acute myocardial infarction and unstable angina group respectively(P0.01).N-terminal pro-brain natriuretic peptide level was higher immediately after percutaneous coronary intervention than that before in both groups,which showed a significant difference in acute myocardial infarction group(P0.05).N-terminal pro-brain natriuretic peptide level was lower 7 days after percutaneous coronary intervention than that immediately after percutaneous coronary intervention in both groups(P0.05),which was more obvious in the acute myocardial infarction group.The main adverse cardiovascular events rate was 10.6%(7/66) when the baseline of N-terminal pro-brain natriuretic peptide was over 300 pg/mL,and was 6.1%(2/33) when it was lower than 300 pg/mL(P0.05).Conclusion N-terminal pro-brain natriuretic peptide level changes dynamically in patients with acute coronary syndrome after percutaneous coronary intervention,and is correlated with the disease severity and the prognosis.