Assessment of the relationship between serum uric acid level and atherosclerosis burden in patients undergoing coronary angiography in Ekbatan (Farshchian) hospital, Hamadan 2015

Abstract Background Nowadays, cardiac disease is the most widespread reason of death in most countries such as Iran. Some studies have correlated serum uric acid level with risk of death in the patients of acute coronary syndrome. The study aimed to determine if there is any correlation between serum uric level and atherosclerosis burden. Material and methods In this cross-sectional study, all the patients underwent coronary angiography in Hamadan's Ekbatan Hospital in 2015 and were studied in terms of demographic, serum lipid profile, blood glucose and uric acid. Data were obtained from patients' medical records, registered in data sheet and analyzed by spss16 statistical software. Results 140 patients participated in this study of whom 60% were male and 40% female with age mean of 62.92 ± 11.21 years old. Blood uric acid's mean was 6.39 ± 2.16 mg/dl and based on coronary artery involvement range was single vessel disease (6.17 ± 1.91), two vessel disease (6.56 ± 2.17), three vessel disease (6.32 ± 2.01), mild or minimal or patent (6.78 ± 3.16) and in ectatic or slow flow (7.30 ± 0.86) mg/dl, respectively. According to the results of Kruskal–Wallis test, no significant relation was observed between uric acid level and the range of coronary artery involvement (P = 0.60). But, the mean of serum uric acid level in severe Ischemic heart disease was significantly more than acute coronary syndrome (P = 0.04). Conclusion Blood uric acid is not a dependent predictive risk factor of atherosclerosis but through effects on other risk factors it may increase the risk of heart disease.