Body mass index and mortality in patients with pancreatic cancer: A systematic review and meta-analysis of observational studies.

e15293 Background: Obesity is associated with increased risk of developing pancreatic cancer (PaC), but it is unclear whether it influences mortality in patients with PaC. We performed a systematic review and meta-analysis to assess the association between obesity and PaC mortality. Methods: Through a systematic search of major databases and conference proceedings, up to December 2014, we identified observational studies reporting the association between obesity (premorbid body mass index [BMI] ≥ 30 kg/m2) and all-cause mortality in patients with PaC. We estimated summary adjusted hazard ratio (aHR) with 95% confidence intervals (CI), comparing highest BMI category with normal reference category in each study, as well as mortality risk per 1kg/m2 increase in BMI, using random effects model; heterogeneity was measured using the inconsistency index (I2). Results: We identified 10 studies (including 3 pooled cohort studies) with 3,349,338 people, of whom 23% were obese. On meta-analysis, compared with PaC pa...