Clinical and pathological features and prognostic factors in young patients with endometrial carcinoma

Objective To investigate the clinical features, pathological features and prognostic factors of young patients with endometrial cancer. Methods One hundred and ten cases of endometrial cancer under 40 in Jiangning Hospital Affiliated to Nanjing Medical University from January 1st 2008 to January 1st 2012 were selected as the study group while one hundred and ten cases of cervical cancer over 40 in the same period as the control group.The clinical features and pathological features were compared between the two groups.Univariate and multivariate analysis were used to determine the prognostic factors. Results The occurrence rate of abnormal vaginal bleeding (74.5% (82/110) ), vaginal drainage (22.7% (25/110) ) and infertility (38.2% (42/110) ) in the study group were significantly lower than those in the control group (59.1%(65/110), 4.5%(5/110), 3.6%(4/110), χ2=4.30, 12.23, 16.53, P 0.05). There were differences in histology, PR, muscle, and lymph node metastases (χ2=5.39, 4.29, 4.89, P<0.05). Multivariate analysis of prognostic factors in young patients with endometrial cancer showed that histology, PR and muscle metastasis were independent risk factors for the prognosis of young endometrial cancer patients. Conclusion There are differences in clinical features and pathological features between young and elderly endometrial cancer patients.The census and prevention among young women should be strengthened and the individualized treatment and the prevention and control system should be upgraded. Key words: Endometrial cancer; Clinical features; Pathological features; Prognostic factors