Technical Aspects of Pancreas Transplantation with Portal Venous Drainage

Vascularized pancreas transplantation was initially developed as a means to re-establish endogenous insulin secretion responsive to normal feedback controls and has evolved over time to a form of auto-regulating total pancreatic endocrine replacement therapy that reliably achieves a euglycemic state and normal glucose homeostasis without the need for either exogenous insulin therapy or close glucose monitoring.