Patient Survival and the Combination of Vitamin D and Phosphorus Binder in

RESULTS: During the follow-up period, 132 deaths (63 cardiovascular and 69 non-cardiovascular deaths) occurred. Compared with the patients who used vitamin D and phosphorus binder concomitantly (n 269), all-cause mortality was higher in patients using neither drug (n 36, hazard ratio [HR] 3.53, 95% CI 1.39-8.94, p 0.008), using phosphorus binder alone (n 115, HR 2.16, 95% CI 1.19–3.90, p 0.011), and using vitamin D alone (n 46, HR 1.38, 95% CI 0.55-3.46, p 0.496) after adjustment with possible confounders. The advantage for patients who used both drugs concomitantly was also signifi cant in cardiovascular mortality, but not in non-cardiovascular mortality. CONCLUSIONS: The combination of vitamin D and phosphorus binder was signifi cantly related to survival in dialysis patients.