Genomic Evidence for a Case of Reinfection with SARS-CoV-2

The degree of protective immunity conferred by infection with SARS-CoV-2 is currently unknown.  As such, the possibility of reinfection with this virus is not well understood.  Herein, we describe the data from an investigation of two instances of SARS-CoV-2 infection in the same individual.  Through nucleic acid sequence analysis, the viruses associated with each instance of infection were found to possess a degree of genetic discordance that cannot be explained reasonably through short-term in vivo evolution.  We conclude that it is possible for humans to become infected multiple times by SARS-CoV-2, but the generalizability of this finding is not known. Funding Statement: Nevada IDEA Network of Biomedical Research (INBRE) supported this work and the publication was made possible by grants from the National Institute of General Medical Sciences (GM103440 and GM104944) from the National Institutes of Health. Declaration of Interests: Missing. Ethics Approval Statement: Missing.