Pregnancy Outcomes in Couples with Males Exposed to Longterm Anti–tumor Necrosis Factor–α Inhibitor Therapies: A Prospective Study

Objective To examine the pregnancy achievement and outcomes in couples where men with spondyloarthritis (SpA) were exposed to tumor necrosis factor inhibitors (TNFi). Methods Pregnancies of SpA fathers were prospectively collected by 6 Romanian rheumatology centers. Results Twenty-seven patients achieved 33 pregnancies and fathered 30 healthy children. Three elective abortions (personal reasons) and no spontaneous abortions, preeclampsia/ eclampsia, stillbirths, congenital malformations or pathologies in the children were recorded. Five patients showed normospermia before and after long term TNFi treatment. Conclusion Pregnancy and child outcome in male SpA patients exposed to long term TNFi therapy was reassuring.