Abstract 20474: Comparative Efficacy of Angiotensin Converting Enzyme Inhibitor and Angiotensin Receptor Blocker for Patients With Acute Myocardial Infarction and Renal Dysfunction

Introduction: Angiotensin converting enzyme inhibitors (ACEi) reduce mortality in patients with acute myocardial infarction (AMI) and heart failure. Recent trials showed that angiotensin receptor blockers (ARB) was not inferior to ACEi with better tolerability. Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease. ACEi and ARB were also key drugs for slowing the progression of CKD Hypothesis: This study sought to assess the clinical outcomes and efficacy of ACEi compared to ARB in patients with AMI and renal dysfunction. And the use of ACEi or ARB might show better clinical outcomes. Methods: A total of 3057 patients with renal dysfunction (CKD-EPI estimated glomerular filtration rate <60mL/min/1.73m2) who undertook percutaneous coronary intervention (PCI) were analyzed from the Korea Acute Myocardial Infarction Registry (KAMIR). They were divided into three groups [Group I: ACEi (n=1511), Group II: ARB (n=921), Group III: neither treatment (n=625)]. The cumulative incidence...