Metabolic response to oral lipid overload in diabetes and impaired glucose tolerance

Abstract Post-prandial hyperglycemia and hypertriglyceridemia have been related to atherogenesis. The aim of this study was to evaluate the response of plasma lipoproteins to a lipid overload in subjects with diabetes (DM), impaired glucose tolerance (IGT) and normals (N). Seventy-seven subjects were selected, 36–85 years, plasma glucose ( G )  G n  = 37; IGT, 2 h G 140–200 mg/dl, n  = 20; and DM, previous diabetes or 2 h G  > 200 mg/dl, n  = 20. They were submitted to a clinical evaluation and an oral lipid overload (1000 kcal, 58% fat). Fasting, 4 and 6-h blood samples after the meal were collected for G , insulinaemia (I), TG, cholesterol and their fractions, and HOMA-IR. Fasting and post-lipid overload lipoproteins were similar between groups, but 6 h TG was still high in DM versus IGT and N as compared to their 4 h values. There was a positive correlation between fasting TG versus 6 h TG ( r  = 0.78, p