The correlation of serum GGT with glucose level in patients with type 2 diabetes

Objective To explore the association between serum gamma glutamyl transpeptidase (GGT) and fasting blood-glucose, evaluating the modification effects of body mass index (BMI), age, sex, and lipids. Methods The normal control group (120 cases), the hospitalized patients with three times of the average fasting blood glucose (6.0~7.0 mg/dl) (128 cases), and the hospitalized patients with three times of the average fasting blood glucose (>7.0 mg/dl) (124 cases) were selected in this study. Immune turbidimetry was used to test the serum of GGT, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total cholesterol (TC), and triglycerides (TG). Enzymatic method was used to test glucose (GLU). High performance liquid chromatography-electrospray mass spectrometry was used to measure glycosylated hemoglobin A1c (HbA1c) in the blood. Results ⑴ The value of GGT was significantly higher in the patients with type 2 diabetes, but the fasting blood glucose was above of 7.0 compared to the other two groups (P<0.05). ⑵ After adjustment of many confounders, the significance of the highest GGT quartile band compared to the lowest was obviously among three groups (P<0.05). Conclusions GGT is expected to predict the development of disease in the process of treatment of type 2 diabetes. Key words: Diabetes mellitus, type 2/ME; Gamma-glutamyltransferase/ME; Blood glucose