SP1-21 Correlation of mild bone fragility and related indicators of biological markers or ultrasonic bone densitometry in a normal Japanese population

Introduction Mild bone fragility has the potential to become a significant national problem given the ageing society as it is a pre-curser of osteoporosis. Methods Trabecular bone mineral density (BMD), bone elastic modulus (BEM) were measured. We also measured serum bone related antiresorptive markers (eg, calcium), bone absorption markers (TRACP-5b, pyridinoline) and bone formation markers (BAP). Various indicators were compared using χ 2 test or trend analysis in the nominated groups. Results We recruited 348 participants (mean age 45.3 years). We divided subjects into four subgroups: Group C (n=258, 74.1%), Group HBD (hypo BMD, n=22, 6.3%), Group HEM (hypo BEM, n=15, 4.3%), and Group DH (dual hypo, n=53, 15.2%), 22 (6.3%). Significant associations were found between HBD/HEM and increased HbA1c. The BAP level was significantly higher in Group HBD than in Group C. TRACP-5b was significantly higher in Group HEM than in Group C (p Conclusion Among the groups, approximately 26% showed mild bone fragility. Group HBD had a correlation with bone formation marker, whereas Group HEM showed a correlation with bone absorption markers. This implies that BMD and BEM seem to reflect different underlying bone metabolism processes. The present results indicate that bone check-up investigations for and medical prevention of osteoporosis are strongly recommended.