Comparison of three different induction regimen in nasopharyngeal cancer: CF versus DC versus DCF.

6075 Background: The standard treatment of local advanced nasopharyngeal cancer is chemoradiotherapy. There is no enough data about the induction therapy. In this study we retrospectively examined patients treated with induction therapy and chemoradiotherapy. Methods: Locally advanced nasopharyngeal cancers patients were included into the study who were treated between 1996-2013 in our clinic. Three different induction regimen were administered to our patients in different time periods; CF, DC and DCF. The dosage of the regimens as follows: CF regimen; cisplatin 50 mg/ m2 1-2 days , fluorouracil 500 mg/ m2 1-5 days, DC; docetaxel 75 mg/ m2 1.day, cisplatin 75 mg /m2 1.day and DCF; docetaxel 75 mg/ m2 1.day, cisplatin 75 mg / m2 1.day, 5-fu 750 mg/ m2 1-5 days. Results: One hundred fifty-four patients were included, 76% (n= 117) of the patients was male and 24% (n= 37) of them female. Median age at diagnosis was 47 (20-73). Most of the patients were at stage III (36.4%) and stage IV (51.7%). In terms of in...