P529 Effect of the combination therapy of intensive granulocyte and monocyte adsorption apheresis and thiopurines in patients with early-diagnosed Crohn's disease

cells (3000 5000/ml) and the concentration of 6-thioguanine (235 400 pmol/8×108 RBCs). Clinical remission was defined as Crohn’s Disease Activity Index (CDAI) of less than 150 points. We classified patients into two groups according to the initiating time of thiopurines after diagnosis of CD as follows: early induction group (starting thiopurines 1.5 years). We evaluated the effect of early induction of thiopurines on long-term clinical remission between two groups. Results: (1) Cumulative remission-maintenance rate of 51 CD-patients with achieving clinical remission was 65.7% at 85.0 months. (2) A comparison of differences in characteristics revealed that cumulative remission-maintenance rate in patients without history of surgery was higher than that in patients with it (74.3% at 85.0 months vs. 47.1% at 77.6 months; p = 0.05). (3) 29 and 22 of 51 patients with achieving clinical remission were categorized into early induction group and late induction group, respectively. Cumulative remissionmaintenance rate of early induction group was significantly higher than that of late induction group (72.1% at 85.0 months vs. 56.1% at 77.6 months; p < 0.05). Conclusions: Early induction of thiopurines would contribute to long-term clinical remission in patients with CD.