Sa1084 Antibiotic Associated Diarrhea: Incidence, Risk Factors and Treatment

Background: The average age of first childbirth is increasing in the United States, as well as the proportion of women who choose not to have children or have a smaller family size. Previous research identified lower parity in women with IBD compared to the general population due to disease-related pregnancy concerns. IBD management has changed over the past decade with the addition of biologic therapies, potentially altering IBD-related pregnancy concerns in women with IBD. We sought to explore disease-related pregnancy concerns and their effect on parity and future reproductive planning in a subset of women with IBD. Methods: Female reproductive age Crohn's and ulcerative colitis patients in an academic practice were identified by electronic database query, sent an opt-out letter, and then contacted for phone survey. Questions included demographics, medical and reproductive history, and plans for future pregnancy. Women were asked if IBD has affected their decision to become pregnant and, if so, a qualitative response on specific concerns was recorded. Qualitative data was coded and frequencies and proportions calculated. We analyzed quantitative data with Stata V11 (College Station, TX) and used Chi-square and Wilcoxon rank-sum tests, as appropriate. Results: 121 female participants (31% response rate) were predominately white (85%), had at least some college education, and a mean age of 34.2 years (SD 6.2). 60% had Crohn's, 30% had IBD-related surgery, 36% were on biologic therapy, and 30% on immunomodulators. 43% had at least one child, 58% desire a future pregnancy, and 54% reported IBD-related pregnancy concerns. Of the 70 women who desire a future pregnancy, the median parity was significantly higher in those with IBD-related concerns (0, range 0-3) compared to those without concerns (0, range 0-2) [Table 1]. IBD-related concerns did not affect the parity in women without a desire for future pregnancy [Table 1]. Women who desire a future pregnancy were more concerned about adverse pregnancy outcomes than those who do not and only four women (3.3%) identified IBD-related concerns that led to a smaller family size than desired [Table 2]. Conclusion: Reproductive planning is multi-faceted for every woman. These data suggest IBD-related concerns are less likely to affect a woman's planned family size than previously reported. The concern for adverse pregnancy outcomes is more common in women with IBD desirous of future pregnancy, suggesting a need for targeted counseling to moderate risk perception. Comparison of participant parity by future pregnancy desire and IBD-related pregnancy concerns