Efficacy and safety of on-demand oral tadalafil in the treatment of men with erectile dysfunction in Taiwan: a randomized, double-blind, parallel, placebo-controlled clinical study.

ABSTRACT Introduction Tadalafil is a phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction (ED). Past clinical trials have assessed its efficacy and safety in western populations. Tadalafil has not been investigated in a large clinical trial with a South‐east Asian population. Aim To assess the efficacy and safety of on‐demand tadalafil for the treatment of ED in a 12‐week, double‐blind, placebo‐controlled study in Taiwan. Methods Men with mild to severe ED of various etiologies were randomized to receive placebo, tadalafil 10 mg, or tadalafil 20 mg, taken as needed (maximum once daily). Efficacy assessments included the International Index of Erectile Function, the Sexual Encounter Profile (SEP) diary, and a Global Assessment Question (GAQ). Results Tadalafil significantly improved erectile function compared with placebo ( P Conclusions Tadalafil was an effective, well‐tolerated therapy for men in Taiwan with ED of broad‐spectrum severity and etiology.