The influence of body mass index and the early graft function in Kidney transplant recipient from brain and cardiac death donors

Objective To investigate the correlation between body mass index (BMI) and early graft function of kidney transplantation from brain and cardiac death donors(DBCD). Methods A retrospective analysis of the clinical data of kidney transplantation from DBCD in our hospital from September 2011 to August 2015 was done.According to the Adult Obesity and Overweight Standard commonly used in China, these patients were divided into three groups: emaciation group(BMI 23.9 kg/m2). The laboratory indexes[blood urea nitrogen (BUN), serum creatinine(Scr), fasting blood glucose, hemoglobin, serum albumin, uric acid, total cholesterol and triglyceride]and the incidence of delayed graft function(DGF) at one week after transplantation were compared among three groups, and graft survival rates one year after operation were compared among three groups. The correlation between Scr and BMI was analyzed. Results There was no difference in Scr level among three groups during the follow-up of 1 year (P>0.05). The BUN, Scr, fasting blood glucose, hemoglobin, serum albumin, uric acid, total cholesterol, triglyceride and DGF of the three groups showed no difference with statistical significance(P>0.05) .Following-up one week and one year, the Scr level of renal transplant recipients was uncorrelated with BMI (r=0.094, P=0.412; r=0.124, P=0.286), and graft survival rates in emaciation group was lowest among the three groups(P<0.05). Conclusions BMI does not affect the recovery of early graft function in kidney transplantation DBCD, it is necessary to increase the weight of the thinner patients before operation, which is helpful to the survival of the actuarial patient and grafts. Key words: Kidney Transplantation; Body Mass Index; Brain Death