SAT0093 High triglycerides and low hdl lipid profile as a surrogate marker of hdl dysfunction in ra: potential links with inflammation and oxidative status

Background the interactions between inflammation and lipid profile in RA are poorly understood. The study of lipid profiles in RA has been biased towards lipoprotein levels, whereas those of triglycerides (TG) and lipoprotein functionality have been neglected. Objectives since recent findings point to an emerging role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low HDL levels (TGhighHDLlow) in RA. Methods lipid profiles were analyzed in 113 RA patients, 113 healthy controls (HC) and 27 dyslipemic subjects (DL). A group of 13 biological-naive RA patients was prospectively followed for 3 months upon TNFα-blockade. Serum levels of inflammatory mediators were assessed by immunoassays. PON1 activity and Total Antioxidant Capacity (TAC) were quantified in serum. PON1 rs662 status was evaluated by RT-PCR Results the prevalence of the TGhighHDLlow profile was similar among RA patients (29/113), HC (30/113) and DL (11/27), linked to higher TRL levels in all groups. However, this profile was associated with increased CRP (p=0.012), TNFα (p=0.004), MCP-1 (p=0.004), IP-10 (p=0.018) and leptin (p 0.050). As expected, QQ-patients exhibited a lower PON1 activity compared to the other genetic variants (both p Conclusions the TGhighHDLlow profile is associated with systemic inflammation, increased TRL levels, decreased PON1 activity and a poor clinical outcome upon TNFα-blockade in RA. Overall, these findings support the link between inflammation and lipid profile, oxidative status and TRL having a pivotal role. The TGhighHDLlow profile can be proposed as a surrogate marker of HDL dysfunction in RA. Disclosure of Interest None declared