TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways

Jing Zhao,Ming Han,Li Zhou,Pu Liang,Yun Wang,Shenghu Feng,Hongping Lu,Xiaoxue Yuan,Kai Han,Xiaofan Chen,Shunai Liu,Jun Cheng

TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFβ1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways

2019

Jing Zhao
Ming Han
Li Zhou
Pu Liang
Yun Wang
Shenghu Feng
Hongping Lu
Xiaoxue Yuan
Kai Han
Xiaofan Chen
Shunai Liu
Jun Cheng

Background This study aimed to investigate the roles and mechanisms of tenofovir alafenamide fumarate (TAF)/tenofovir disoproxil fumarate (TDF) in treating liver fibrosis.

Keywords:

Signal transduction
Tenofovir
Cancer research
Diabetes mellitus
NF-κB
Inflammasome
liver fibrosis
Virology
Medicine
Tenofovir alafenamide
Mothers against decapentaplegic homolog 3
Hepatic stellate cell
Knockout mouse
Gene silencing

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