The Influence of Changes of Central Nerve Function on Praxiology and Respiratory Resistance of Asthma Guinea Pigs

Objective Peripheral nerve and mind state both play important roles during the happening of asthma. There was no study told whether central nerve affect the process of asthma. Our experiment is to discover the influence of changes of central nerve function on asthma. Methods Sixteen guinea pigs were divided into four groups which were control group, saline group, MEK inhibitor (PD98059) group, MEK stimulant (Aurintricarboxylic-acid) group. Each group comprised four cavies. After injecting saline, MEK inhibitor (PD98059), MEK stimulant (Aurintricarboxylic-acid) into the guinea pigs lateral ventricle, by using ”U” type manometric tube and ultraviolet spectrophotometer we observed the influence of central nerve system’s function changing on the guinea pigs behavior, respiratory resistance and airway exudation. Results In PD58059 group, the variation of praxiology and respiratory resistance is small (0.42±0.05)cmH2O. In Aurintricarboxylic -acid group, the variation of praxiology and respiratory resistance is abvious (1.45±0.15) cmH2O and has significant difference with NS control group. Conclusion The changes of central nerve function have influence on praxiology and respiratory resistance of asthma.