Effect of adjuvant chemotherapy on bone resorption marker beta C-telopeptide (B-CTX) in postmenopausal women

594 Background: In NCIC CTG MA.14, a randomized trial of tamoxifen versus tamoxifen + octreotide LAR, we found a measure of bone resorption, serum B-CTx, to be significantly associated with bone-only first recurrence. Administration of chemotherapy was permitted, and chemotherapy was a stratification factor (never, concurrent, sequential). It was unclear whether pretrial B-CTx serum levels would be affected by prior administration of chemotherapy, and whether timing of chemotherapy was associated with who had bone only, or bone and other site relapse. Methods: Serum B-CTx concentration (Serum CrossLaps Nordic Biosciences, Copenhagen, DN) was determined pretrial therapy in 621 of 667 primary breast cancer patients on MA.14. We tested for differences in continuous B-CTx levels in those who had assessment before (any) chemotherapy (included those who had none) versus those who were assessed after chemotherapy with an ANOVA test. We also used exact Fisher tests to examine whether there was an association betw...