FRI0545 HEMODYNAMIC MEASUREMENTS AND ARTERIAL STIFFNESS IN PATIENTS WITH JUVENILE IDIOPATIC ARTHRITIS COMPARED TO CHILDREN WITHOUT JUVENILE IDIOPATIC ARTHRITIS

Background Juvenile Idiopathic Arthritis (JIA) can cause long-term cardiovascular complications. There are non-invasive, validated, easy to perform methods for cardiovascular testing, such as: carotid intimal-media thickness (cIMT), and measurement of arterial rigidity through carotid distensibility, carotid-femoral pulse wave velocity (cfPWV) and the augmentation index (AIx). Objectives To compare the main hemodynamics measurements (cIMT, carotid distensibility, cfPWV and AIx) between JIA and non-JIA subjects. Methods Analytical cross-sectional study in subjects 5 to 16 years of age. Two groups: patients with JIA according to the ILAR classification without any other condition vs healthy children. Measurements: somatometry, laboratory (glucose, creatinine, lipid profile), disease activity index (JADAS-27) and hemodinamic variables (cIMT, carotid distensibility, cfPWV and AIx). Results 63 JIA subjects and 50 healthy controls were included, mean age 11.5 ± 2.8 vs 10.7 ± 3.2 years (p = 0.17) and 70% vs 54% females, respectively. Both groups were also similar (p > 0.05) for nutritional state, sedentary lifestyle, smoking habits and family history of cardiovascular risk. Table 1 show lipid profile of both groups. Subtypes of JIA were: RF positive polyarthritis (29%), RF negative polyarthritis (29%), oligoarthritis (19%), enthesitis-related arthritis (14%) and systemic arthritis (9%). Mean time of disease evolution was 4 ± 3 anos. There were no significant differences between groups in the main hemodinamic parameters (table 2). When comparing inactive vs active disease and active disease vs controls there were no differences either, we found a discrete trend to less carotid distensibility and higher cfPWV in patients with active disease compared to controls [0.63 ± 0.17 mm vs 0.66 ± 0.15 mm (p = 0.94) and 6.12 ± 2.88 m/s vs 5.42 ± 0.75 m/s (p = 0.33), respectively]. 59% of subjects with JIA were inactive according to JADAS-27. When considering time of disease evolution, children with 0-4 years vs children with >4 years and children with >4 years vs controls, we found differences in cIMT [0.41 ± 0.62 mm vs 0.44 ± 0.50 mm (p = 0.02) and 0.44 ± 0.50 mm vs 0.40 ± 0.70 mm (p = 0.01), respectively]. Finally, cfPWV was higher in patients with 0-4 years than in patients with >4 years of evolution (p = 0.01). Conclusion We found a tendency to increased cardiovascular risk when the disease has more than 4 years of evolution, specially in patients with persistent active disease. Traditional and non-traditional cardiovascular risk factors add up in this population. We need longterm follow-up studies. References [1] Bohr AH, Fuhlbrigge RC, Pedersen FK, De Ferranti SD, Muller K. Premature subclinical atherosclerosis in children and young adults with juvenile idiopathic arthritis. A review considering preventing measures. Pediatr Rheumatol2016; 14: 1-5. [2] Sozeri B, Atikan BY, Ozdemir K, Mir S. Assessment of vascular function in systemic onset juvenile idiopathic arthritis. Clin Rheumatol2016; 35: 1699-1703. Disclosure of Interests Jorge E. Rubio Silveira Grant/research support from: Grants from Roche and Abbvie for some national meetings, C. Araceli Arellano Valdez Grant/research support from: Grants from Roche for multiple national and international meetings., Speakers bureau: different conferences about Tocilizumab in meetings., Carlos Ramos Becerra: None declared, Myriam Mendez Nunez: None declared, David Cardona Muller: None declared, Oscar Mares Flores: None declared, Priscila Vega Garcia: None declared, Fernando Grover Paez: None declared, Alberto Tlacuilo Parra: None declared