Vernix caseosa–like hyperkeratotic plaques in a french canadian infant

A male infant was born at 34 weeks’ gestation with generalized hyperkeratotic plaques on the limbs along with extensive areas of vernix caseosa–like changes on the head and trunk. ### Prenatal and Birth Histories ### Presentation (Day of Birth) At birth, striking skin changes were noted in the form of generalized edematous spongy hyperkeratotic plaques on the limbs along with extensive areas of vernix caseosa–like changes on the head and trunk (Fig 1). The amniotic fluid appeared thickened because of the presence of skin debris. The infant did not have any respiratory distress. The infant was placed in an incubator with 60% to 70% humidity. Figure 1. Generalized verrucous hyperkeratosis and vernix caseosa–like changes. ### Physical Examination (Day of Birth) ### Laboratory Studies