Effects of NMDA receptors on hyperalgesia

NMDA receptors are a subtype of excitatory transmitters-glutamate receptor in the central nervous system.They belong to ionotropic receptors and play an important role in many complex physiological andpathological processes,including wind-up,central sensitization,long-term potentiation,peripheral sensitization,visceral pain,cellular necrosis and apoptosis,as well as induction and maintenance of the hyperalgesia.Studyon effects of NMDA receptors on hyperalgesia provides a wide strategy and prosperity for a novel class ofanalgesics.