Abstract 10883: Ischemia-Modified Albumin in Acute Decompensated Heart Failure: IMA-HF Study

Purpose: Ischemia-modified albumin (IMA) is a sensitive marker of ischemia, even in the absence of myocardial damage. IMA has also been found to be elevated in the setting of oxidative stress, acidosis, hypoxia, free radical injury, inflammatory state and sodium and calcium pump disruptions which are also involved in the pathophysiologic process of heart failure (HF). However, prospective studies examining IMA levels specifically in patients with HF are still lacking. Therefore, the aim of this multicenter, propective study was to evaluate IMA levels and its diagnostic ability in patients presenting with acute decompensated HF. Methods: This prospective study was performed at the five independent sites. Seventy patients admitted to participating centers with clinical signs and symptoms of NYHA III-IV acute decompensated HF and LVEF <35% were enrolled in this study. Serum concentrations of IMA were measured from blood sample collected before the initiation of HF therapy. A control reference population cons...