In-vivo antidiabetic activity of methanolic extract of Corchorus olitorius for the management of type 2 diabetes

Management of type 2 diabetes with an agent having no side effects is still a challenge for the researchers, however if the side effects are lessened & there may be a chance for reduced adverse reactions or severe side effects due to drug interaction. These interactions may be due to either any concomitant drug therapy or any dietary supplements taken together with the drugs. This study sought to evaluate the antidiabetic potentials of methanolic extract of jute leaf (Corchorus olitorius) in diabetic rats. Diabetes was induced in rats by streptozotocin (60mg/kg; i.p.) administration. Oral treatment of methanolic extract of C. olitorius using rat oral needle at 100 and 200mg/kg doses significantly (𝑃<0.001) decreased blood glucose and cholesterol levels in diabetic rats than control rats. In this study, Body weight, blood glucose, HDL, Total Protein, SGOT, SGPT, cholesterol and triglyceride were measured. The results showed that there was a significant decrease (P<0.01) in the blood glucose, cholesterol, total protein, SGOT, SGPT and triglyceride levels in diabetic rats when compared to the normal (control) rats and increase the level of HDL and body wt. In conclusion, the above actions might be responsible for the antidiabetic activity of extract due to presence of gallic acid and other biomarkers.