Role of QuantiFERON-TB-Gold In Tube assay for active and latent tuberculosis infection in investigation of tuberculosis outbreak in a university

Background: Identification and monitoring of active tuberculosis (TB) and latent tuberculosis infection (LTBI) are the key steps to prevent transmission during a TB outbreak. The aim of this study was to evaluate the role of QuantiFERON-TB-Gold In Tube assay (QFT-GIT) in the investigation of active TB and LTBI cases during a TB outbreak in a university. Methods: In this study, enrolled students and teachers were evaluated with chest radiograph, questionnaire, and QFT-GIT test. The diagnosis of active pulmonary TB was based on sputum studies and chest radiographs. The questionnaire, which covered demographic information, underlying diseases, and environmental exposures, was applied to assess the association of risk factors by multiple logistic regressions.